For your information, an article entitled “Fructose replacement of glucose or sucrose in food or beverages lowers postprandial glucose and insulin without raising triglycerides: a systematic review and meta-analysis” by Evans et al. was recently published in the American Journal of Clinical Nutrition. In the present study, Evans et al. conducted a systematic review and meta-analysis to explore the impact of replacing glucose or sucrose with fructose in diabetics and non-diabetics as well as in lean, overweight, and obese populations.
The authors collected data from 47 trials including 81 comparison arms which met the following criteria: 1) the intervention was fructose; 2) the control was either glucose or sucrose; 3) the replacement was isoenergetic (equal number of grams of sugar in each arm); 4) the study was a randomized controlled trial; 5) the study period was ≥45 min postprandial; and 6) the study presented data on peak postprandial blood glucose.
Evans et al. found that 62 study arms substituted fructose for glucose and 19 substituted fructose for sucrose. Results of the subgroup analyses are provided below.
Evans et al. conclude “The finding that postprandial peak blood glucose concentrations were lowered in those consuming fructose was not unexpected…We found that peak blood glucose reductions are more pronounced in individuals with impaired glucose tolerance or type 1 or type 2 diabetes. This reinforces the potential benefits for glycemic control from the isoenergetic exchange of glucose or sucrose in food or beverages with fructose.” The authors also assert that “The results of our systematic review and meta-analysis on isoenergetic exchange of glucose or sucrose by fructose suggest that there are benefits to fructose consumption without concomitant adverse effects on blood lipids.”
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