Human Clinical Trials | |
| Maersk et al, AJCN, 2012 (http://ajcn.nutrition.org/content/95/2/283.full.pdf+html) | |
| Overview |
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| Results |
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| Conclusion excerpt | “The suggestions from observational studies that intake of diet cola can result in obesity, type 2 diabetes, and the metabolic syndrome are not supported by the findings of our current intervention, i.e., that the effect of diet cola on fatness, ectopic fat, and metabolic factors is mainly neutral and very similar to that of water. Also, diet cola was found to have effects nearly similar to milk in reducing blood pressure.” |
| Bryant et al, Eur J Clin Nutr, 2014 (http://www.citeulike.org/article/13097452) | |
| Overview |
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| Results |
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| Conclusion excerpt | “We conclude that there is no consistent evidence that non-nutrient sweeteners, when acutely consumed with glucose in dietetically relevant doses, have a class effect in modulating blood glucose in healthy human subjects. However, acesulfame-K may require further exploration.” |
| Abdallah et al, AJCN, 1997 (http://ajcn.nutrition.org/content/65/3/737.full.pdf) | |
| Overview |
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| Results | No change in plasma glucose, insulin or glucagon after aspartame consumption. |
| Conclusion excerpt | “This study suggested that oral stimulation provided by sweet non-flavored tablets is not sufficient for inducing CPIR.” |
LITERATURE REVIEWS | |
| Gibson et al, Nutrition Bulletin, 2014 (http://onlinelibrary.wiley.com/doi/10.1111/nbu.12116/pdf) | |
| Overview | Consensus statement on benefits of low-calorie sweeteners, International Sweetener Association Conference 2014 |
| Conclusion excerpt | “LCS may have a beneficial effect on post-prandial glucose and insulin in healthy individuals and in people with diabetes.” |
| Magnuson et al, Crit Rev Tox, 2007 (http://bit.ly/1XUbz9X) | |
| Overview | Convene an independent international panel of experts* to review all scientific studies and assess the safety of current consumption of aspartame.
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| Conclusion excerpt | “The weight of existing evidence is that aspartame is safe at current levels of consumption as a nonnutritive sweetener.” . . .“Aspartame does not affect glycemic response in normal or diabetic individuals, and does not affect metabolic control or insulin release.” |
| Pereira, Nutrition Reviews, 2013 (http://bit.ly/1O66FDm) | |
| Overview | To provide a synthesis of the literature on the effects of non-nutritive or artificial sweeteners (ASBs) on body weight, cardiovascular disease, and type 2 diabetes. (review of 34 studies) |
| Results |
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| Conclusion excerpt | “In terms of general public health recommendations or clinical advice, the scientific evidence does not presently support a blanket recommendation to either consume or avoid <low calorie sweetener> consumption in and of itself. However, for individuals who are frequent (several times per week or more) consumers of SSB and are overweight or at risk for weight gain and obesity, it seems reasonable, based on the evidence, to recommend replacing SSBs with either <low calorie sweetened beverages>, water, or other unsweetened low-calorie beverages, such as plain tea or coffee.” |
| Renwick & Molinary, Br J Nutr, 2010 (http://bit.ly/1F2yNEo) | |
| Overview | To explore the interactions between sweeteners and enteroendocrine cells and consequences for glucose absorption and insulin release. (33 studies reviewed) |
| Conclusion excerpt | “Data from numerous publications on the effects of low-energy sweeteners on appetite, insulin and glucose levels, food intake and body weight have shown that there is no consistent evidence that low energy sweeteners increase appetite or subsequent food intake, cause insulin release or affect blood pressure in normal subjects. The data from extensive in vivo studies in human subjects show that low-energy sweeteners do not have any of the adverse effects predicted by in vitro, in situ or knockout studies in animals.” |
Presented at: Academy of Nutrition and Dietetics FNCE 2015
Do you have questions about low-calorie sweeteners? Want to learn more about maintaining a healthy lifestyle? You asked and we listened. Our resident Registered Dietitians answered the most popular questions about low-calorie sweeteners.
