Low- and no-calorie sweeteners and rare sugars are some of the most studied ingredients in the food supply and their safety has been reviewed and upheld by numerous international scientific and regulatory authorities, including the Joint Food and Agriculture Organization and World Health Organization (FAO/WHO) Expert Committee on Food Additives (JECFA), the European Food Safety Authority (EFSA), the U.S. Food and Drug Administration (FDA), Food Standards Australia and New Zealand (FSANZ), Health Canada, and others (see below).